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KMID : 1134820120410010026
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Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 1 p.26 ~ p.32
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Effects of Different Kinds of Salt in the Comutagenicity and Growth of Cancer Cells
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Zhao Xin
Kim So-Hee
Qi Yongcai
Kim So-Young
Park Kun-Young
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Abstract
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Purified salt and several different types of sea salts showed comutagenicity in the presence of MNNG (N-methyl-N'-nitro-N-nitrosoguanidine). However, the salts exhibited anti-cancer effects in HCT-116 human colon carcinoma cells and AGS human gastric adenocarcinoma cells. Sea salt showed less comutagenicity effects than purified salt. French sea salt (Salines de Guerande) and Korean sea salt I, which contained higher levels of minerals, showed less comutagenicity. In MTT assay, when HCT-116 and AGS cancer cells were treated with the salts, French sea salt (36% and 34%) and Korean sea salt I (35% and 33%) showed higher anticancer activities than Spanish sea salt (33% and 31%), Italian sea salt (29% and 27%), Korean sea salt Ⅱ (22% and 22%), or purified salt (18% and 15%) at a salt concentration of 1%. French sea salt and Korean sea salt Ⅰ also showed better anticancer activities than the other salt samples at a low concentration of 0.5% (p<0.05). Apoptosis related genes of Bax and Bcl-2 were regulated by the treatment of the salt in the colon cancer cells. French sea salt and Korean sea salt I especially increased Bax mRNA expression, but decreased Bcl-2 expression, indicating that they can induce apoptosis of the cancer cells. From the experimental results, sea salt showed better health functional effects than the purified salt, and French sea salt and Korean sea salt Ⅰwhich contained high levels of Ca, K, and Mg showed better effects.
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KEYWORD
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sea salt, mineral, comutagenicity, anticancer effect, human cancer cells
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